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Preoperative systemic inflammatory markers are prognostic indicators in recurrent adrenocortical carcinoma
Author(s) -
Gaitanidis Apostolos,
Wiseman Douglas,
el Lakis Mustapha,
Nilubol Naris,
Kebebew Electron,
Patel Dhaval
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25760
Subject(s) - medicine , hazard ratio , adrenocortical carcinoma , confidence interval , univariate analysis , gastroenterology , lymphocyte , multivariate analysis , neutrophil to lymphocyte ratio , transthyretin , surgery
Background Recurrent adrenocortical carcinoma (ACC) has a poor prognosis with minimal clinical and biochemical factors to guide management. The aim of this study was to evaluate the prognostic significance of systemic inflammatory response in patients with recurrent ACC. Methods Patients who underwent resection for recurrent ACC were retrospectively analyzed. Preoperative neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, lymphocyte‐to‐monocyte ratio (LMR), and mean platelet volume were calculated. Results Twenty‐five patients (age at operation 52.2 ± 9.5 years) were identified. We observed a statistically significant shorter disease‐specific survival (DSS) in patients with LMR less than 4 (41 ± 7.4 months vs 71 ± 12.3, P = .023) and male sex (26.6 ± 4.2 months vs 57.6 ± 9.5 months, P = .079), while time‐to‐recurrence (TTR) less than 12 months (40 ± 7.7 months vs 70.3 ± 13.1 months, P = .059) had a trend on univariate analysis for worse DSS. On multivariable analysis, LMR < 4 (hazard ratio [HR] 4.18; 95% confidence interval [CI]: 1.18‐14.76; P = .027) and TTR less than 12 months (HR 2.77 95% CI: 1‐7.62; P = .049) were found to be significantly associated with worse DSS. Conclusion Preoperative LMR greater than 4 and TTR greater than 12 months are associated with longer DSS. Patients with LMR greater than 4 and TTR greater than 12 months may benefit from a more aggressive therapeutic approach and may require less frequent surveillance.