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Treatment outcome of chest wall soft tissue sarcomas: Analysis of prognostic factors
Author(s) -
Nakahashi Naoya,
Emori Makoto,
Tsuchie Hiroyuki,
Nagasawa Hiroyuki,
Sonoda Tomoko,
Takada Kohichi,
Miyajima Masahiro,
Watanabe Atsushi,
Shimada Yoichi,
Yamashita Toshihiko
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25708
Subject(s) - medicine , multivariate analysis , hazard ratio , confidence interval , soft tissue , soft tissue sarcoma , surgery , chemotherapy , sarcoma , primary tumor , radiology , oncology , cancer , pathology , metastasis
Background Primary soft tissue sarcomas (STSs) involving the chest wall are uncommon. The aim of this study was to identify factors that influence the prognosis of patients with primary chest wall STS. Methods The records of 38 patients (23 men and 15 women) who were treated at our institutions during 2002 to 2018 were reviewed. The following variables were evaluated as potential prognostic factors: sex, tumor size, chemotherapy, and completeness of surgical margins. Multivariate analysis was conducted to identify predictors of overall survival (OS) and disease‐free survival (DFS). Results Of the 38 included patients, 5 had low‐grade tumors and 33 had high‐grade tumors. Five patients required chest wall reconstruction including rib resection. Thirty patients (79%) underwent R0 resection. The 5‐year OS and DFS rates were 45% and 27%, respectively. Local recurrence developed in 7 patients. Multivariate analysis identified tumor size (hazard ratio [HR]: 4.13; 95% confidence interval [CI]: 1.05‐16.24; P = .04) and R1/2 resection (HR: 3.92; 95% CI: 1.12‐13.66; P = .03) as predictors of OS. Conclusions Prognostic factors for survival included tumor size and completeness of surgical margins. Complete tumor excision is desirable, particularly in cases of early detection.