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Screening and surgical prophylaxis for hereditary cancer syndromes with high risk of endometrial and ovarian cancer
Author(s) -
Bercow Alexandra S.,
Eisenhauer Eric L.
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25645
Subject(s) - medicine , lynch syndrome , endometrial cancer , ovarian cancer , hysterectomy , prophylactic surgery , oophorectomy , gynecology , cancer , mastectomy , prophylactic mastectomy , breast cancer , oncology , surgery , dna mismatch repair , colorectal cancer
Abstract In the era of advanced cancer genomics, our recognition of hereditary cancer mutations continues to increase. Two of these conditions, which carry an increased risk of female cancers including endometrial, ovarian, breast, are hereditary breast and ovarian cancer syndrome and Lynch syndrome. Risk‐reducing surgery, such as mastectomy, salpingo‐oophorectomy, and hysterectomy may decrease cancer risk for mutation carriers. Background, indications, techniques, and consequences of these surgical procedures are reviewed.