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Significance of lymph node involvement in local recurrence of colorectal cancer
Author(s) -
Dumont Frédéric,
Muñoz Miguel A.,
Franco Valéria,
Wernert Romuald,
Verriele Valérie,
Heyman MarieFrançoise,
Kerdraon Olivier,
Capitain Olivier,
GuerinMeyer Véronique,
Raimbourg Judith,
Senellart Hélène,
Hiret Sandrine,
Raoul JeanLuc,
Thibaudeau Emilie
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25631
Subject(s) - medicine , lymphovascular invasion , colorectal cancer , concomitant , lymph node , rectum , lymphatic system , odds ratio , lymph , multivariate analysis , urology , cancer , oncology , gastroenterology , metastasis , pathology
Background There are few data on lymphatic spread concomitant to local recurrence (LR) of colorectal cancer (CRC). The objectives of this study were to determine variables associated with lymphatic spread, to analyze the distribution of LN+, and understand the underlying mechanisms. Methods A total of 76 patients underwent resection of LR of CRC between January 2007 and December 2018 at Institut cancérologique de l’Ouest and were retrospectively reviewed. Results Twenty‐five (32.9%) patients had lymph node (LN) involvement with LR. Lymphatics from the mesocolon‐rectum and aorto‐iliac compartments were involved in 21%, 20.3% and 18.1%, 20.3% for pelvic and retroperitoneal LRs, respectively. In multivariate analysis, the only predictive factor for LN invasion (LN+) was a primary positive LN status (odds ratio, 5.3; P = .007). Despite a trend toward a worse median overall survival in the LN+ group, the difference was not significant in comparison with the LN− group (46 vs. 57 months; P = 0.31) or with the LN− plus LN not assessed groups (46 months vs not reached; P = .07). Conclusions LN invasion with LR from CRC is a frequent occurrence without significant impact on survival. The only predictive factor is a primary positive nodal status.