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Secondary angiosarcoma: A fatal complication of chronic lymphedema
Author(s) -
Farzaliyev Farhad,
Hamacher Rainer,
Steinau Professor HansUlrich,
Bertram Stefanie,
Podleska Lars Erik
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25598
Subject(s) - medicine , lymphedema , angiosarcoma , surgery , complication , secondary lymphedema , fascia , melphalan , lesion , breast cancer , cancer , chemotherapy
Secondary Angiosarcoma (Stewart‐Treves Syndrome) is a rare malignant cutaneous lesion, which arises in chronic lymphedema of the extremity, often observed after breast cancer treatment. We reviewed the history and the oncological outcome of two patients with this disease. Multimodal therapy including hyperthermic isolated limb perfusion with TNF‐alpha and Melphalan, combined with radical resection of the affected skin and subcutaneous tissue including the fascia, with large safety margins may probably lead to better survival.