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The degree of sclerosis is associated with prognosis in well‐differentiated liposarcoma of the retroperitoneum
Author(s) -
Chrisinger John S. A.,
AlZaid Tariq,
Keung Emily Z.,
Leung Cheuk,
Lin Heather Y.,
Roland Christina L.,
Torres Keila E.,
Benjamin Robert S.,
Ingram Davis R.,
Khan Samia,
Somaiah Neeta,
Amini Behrang,
Feig Barry W.,
Lazar Alexander J.,
Wang WeiLien
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25585
Subject(s) - medicine , multiple sclerosis , liposarcoma , pathology , radiology , sarcoma , psychiatry
Background and Objectives Well‐differentiated liposarcomas (WDL) are often partly composed of sclerotic tissue, however, the amount varies widely between tumors, and its prognostic significance is unknown. We hypothesized that tumors with more sclerosis would behave more aggressively. Methods Primary retroperitoneal WDL from 29 patients resected at our institution with follow‐up were histologically evaluated by soft tissue pathologists blinded to outcome. Tumors with ≥ 10% sclerosis were designated “sclerotic” while tumors with < 10% sclerosis were designated as “minimally sclerotic”. Cellular and dedifferentiated tumors were excluded. Clinical parameters and radiologic assessments on computed tomography (CT) were recorded. Results Histological evaluation identified 13 minimally sclerotic WDL and 16 sclerotic WDL. Median follow‐up was 9 years (range, 3‐20). Median recurrence‐free survival (RFS) and median overall survival (OS) were 6.16 and 13.9 years, respectively. Compared with patients with sclerotic WDL, those with minimally sclerotic WDL had superior RFS (HR = 0.17 [95% CI, 0.06‐0.53], P = .002) and OS (log‐rank test, P = .002). Sclerotic WDL exhibited higher Houndsfield Units than minimally sclerotic WDL (26 vs 1, P = .040). Conclusions Minimally sclerotic WDL were associated with more favorable outcome compared with sclerotic tumors. Assessment of sclerosis in WDL is likely a useful prognostic marker.