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Physical function and pain intensity in patients with metastatic bone disease
Author(s) -
Janssen Stein J.,
Pereira Nuno Rui Paulino,
Thio Quirina C.B.S.,
Raskin Kevin A.,
Bramer Jos A.M.,
LozanoCalderon Santiago A.,
Schwab Joseph H.
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25510
Subject(s) - medicine , prostate cancer , population , bone metastasis , disease , metastasis , physical therapy , cancer , oncology , environmental health
Background Patient reported outcome data in bone metastatic disease are scarce and it would be useful to have normative data and understand what patients are at risk for poor function and more pain. Objectives We aimed to assess what factors are independently associated with physical function and pain intensity in patients with bone metastasis. Methods We included data from 211 patients with bone metastasis who completed a survey (2014‐2016) including the PROMIS Physical Function Cancer and PROMIS Pain Intensity questionnaires. Results Prostate ( P < .001) and thyroid carcinoma ( P = .007) were associated with better function and having other disabling conditions ( P = 0.035) was associated with worse function. Prostate carcinoma ( P = .001) and lymphoma ( P = .007) were associated with less pain. There was a moderate correlation between pain and function ( P < .001). Function was substantially worse as compared to a US reference population of patients with cancer ( P < .001), whereas pain was slightly less compared to the US general population average ( P < .001). Conclusions Patients with bone metastasis have a poor physical function. Physical function and pain intensity depend on tumor histology, but also on potentially modifiable factors such as other disabling conditions. Level of Evidence Level III, prognostic study.