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Systemic treatment for metastatic colorectal cancer in the era of precision medicine
Author(s) -
Sandhu Jaideep,
Lavingia Viraj,
Fakih Marwan
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25421
Subject(s) - medicine , colorectal cancer , oncology , precision medicine , cancer , targeted therapy , pathology
The treatment of metastatic colorectal cancer has evolved over the last two decades with the FDA approval of several cytotoxic, biological, and targeted agents. In this paper, we review the impact of sidedness, RAS, BRAF, HER‐2 , and other immune biomarkers on metastatic colorectal cancer treatment selection and sequencing in both the palliative and curative intent settings.