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Estrogen receptor beta expression correlates with proliferation in desmoid tumors
Author(s) -
Santti Kirsi,
Ihalainen Hanna,
Rönty Mikko,
Karlsson Christina,
Haglund Caj,
Sampo Mika,
Tarkkanen Maija,
Blomqvist Carl
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25407
Subject(s) - cyclin d1 , tissue microarray , estrogen receptor , medicine , immunohistochemistry , cancer research , breast cancer , cyclin , cyclin e , cyclin d , estrogen receptor alpha , progesterone receptor , cyclin b , estrogen receptor beta , oncology , cell cycle , cancer
Background and objectives Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERβ) and cyclin D1 in desmoid tumors. Methods This study consists of 83 patients with a surgically treated desmoid tumor. ERβ and cyclin D1 expression was examined by immunohistochemistry in tissue microarrays. Cyclin A and Ki67 were studied in our previous work. Results Median ERβ expression was 10.8%. ERβ expression correlated with expression of the proliferation antigens Ki67 ( r p = 0.35, P = 0.003), cyclin D1 ( r p = 0.34, P = 0.004), and cyclin A ( r p = 0.34, P = 0.004). ERβ immunoexpression showed a trend towards predictive impact for recurrence as a continuous variable. Further explorative analysis indicated that very high ERβ expression was related to high risk of relapse (hazard ratio [HR] 2.6; P = 0.02). Median cyclin D1 expression was 15.6%. High cyclin D1 expression was associated with high Ki67 and cyclin A expression. Cyclin D1 was not associated with time to recurrence. Conclusions ERβ and cyclin D1 immunopositivity correlated with high proliferation in desmoid tumors. High ERβ expression might be predictive for postoperative recurrence.