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Call for improved design and reporting in soft tissue sarcoma studies: A systematic review and meta‐analysis of chemotherapy and survival outcomes in resectable STS
Author(s) -
Istl Alexandra C.,
Ruck Jessica M.,
Morris Carol D.,
Levin Adam S.,
Meyer Christian F.,
Johnston Fabian M.
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25401
Subject(s) - medicine , meta analysis , soft tissue sarcoma , chemotherapy , overall survival , oncology , sarcoma , survival analysis , soft tissue , surgery , pathology
New evidence and systemic therapies demand an updated analysis of chemotherapy for soft tissue sarcoma. We completed a meta‐analysis of chemotherapy in localized STS, assessing OS, PFS, and local and distant recurrence (local recurrence‐free survival [LRFS] and distant recurrence‐free survival [DRFS]). Ten studies, totaling 3157 patients, were included. A pooled analysis for 5‐year OS, progression‐free survival, LRFS, and DRFS showed no benefit of chemotherapy over locoregional therapy alone for all‐comers or site‐specific STS. We make recommendations to improve outcome reporting and quality indices.