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Synchronous hepatectomy and splenectomy vs hepatectomy for selected patients with hepatocellular carcinoma and clinically significant portal hypertension: A systematic review and meta‐analysis
Author(s) -
Kong Junjie,
Shen Shu,
Wang Wentao
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25392
Subject(s) - medicine , splenectomy , hepatectomy , hepatocellular carcinoma , perioperative , odds ratio , confidence interval , portal hypertension , meta analysis , surgery , gastroenterology , cirrhosis , spleen , resection
This review aimed to evaluate the safety, feasibility, and effectiveness of synchronous hepatectomy and splenectomy for selected patients with hepatocellular carcinoma and clinically significant portal hypertension compared to hepatectomy alone. A systematic search in electronic databases was conducted. A total of 8 studies including 1445 patients were reviewed. While perioperative safety was satisfactory, synchronous hepatectomy and splenectomy were associated with a significant improvement of 5‐year overall survival (odds ratio = 1.81; 95% confidence interval: 1.35, 2.42; P < 0.0001).