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Hepatocellular carcinoma: resection with adjuvant hepatic artery infusion therapy vs resection alone. A systematic review and meta‐analysis
Author(s) -
Moran Alexandra,
Ramos Lorena Flor,
Picado Omar,
Pendola Fiorella,
Sleeman Danny,
Dudeja Vikas,
Merchant Nipun,
Yakoub Danny
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25338
Subject(s) - medicine , hepatocellular carcinoma , meta analysis , resection , adjuvant therapy , carcinoma , adjuvant , surgery , oncology , radiology , chemotherapy
Hepatocellular carcinoma (HCC) has a recurrence rate of up to 70% in 5 years after resection, detrimentally lowering survival. The role of adjuvant therapy remains controversial; therefore, the aim of this study was to evaluate the disease‐free and overall survival of patients with HCC, not candidates for transplantation, undergoing resection and adjuvant hepatic artery infusion therapy vs resection alone. Our meta‐analysis showed that adjuvant HAIC improves overall and disease‐free survival after resection, especially in tumors ≥7 cm.