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Completion surgery of residual disease after primary inadequate surgery of retroperitoneal sarcomas can salvage a selected subgroup of patients—A propensity score analysis
Author(s) -
Nizri Eran,
Fiore Marco,
Colombo Chiara,
Radaelli Stefano,
Callegaro Dario,
Sanfilippo Roberta,
Sangalli Claudia,
Collini Paola,
Morosi Carlo,
Stacchiotti Silvia,
Casali Paolo G.,
Gronchi Alessandro
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25337
Subject(s) - medicine , referral , surgery , perioperative , propensity score matching , family medicine
Background Patients with retroperitoneal sarcoma (RPSs) who undergo primary inadequate surgery before referral to specialized sarcoma centers may be considered for completion surgery (CS). We wanted to compare the outcome of these patients to those who underwent primary adequate surgery (PAS) at a single referral institution. Methods We identified 34 patients who were referred for CS after primary inadequate surgery. Using a propensity score based on validated RPS outcome risk factors, we managed to match 28 patients to patients with PAS. Results Median time lag between the first and second operation in CS patients was 5 months (2‐15). Surgical extent was similar among groups (median number of organs resected = 3; P = 0.08), and macroscopically complete excision was achieved in all patients. The rate of severe complications did not differ between the groups (1 of 28 vs 3 of 28, respectively; P = 0.35) and no perioperative mortality was documented. Median follow‐up was 43.5 months. Patients in the CS group had similar local recurrence‐free survival (mean, 92.1 ± 9.7 vs 99.8 ± 12.4; P = 0.85) and relapse‐free survival (mean, 88.7 ± 9.8 vs 80.9 ± 12.3; P = 0.3) to those with PAS. Conclusions CS has short‐ and long‐term outcomes comparable to PAS. While primary surgery should always be carried out at a referral institution, some of the patients who undergo an initial incomplete resection at a non specialist center can still be offered a salvage procedure at a referral institution with comparable results.