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Is malnutrition associated with postoperative complications in patients with primary bone sarcomas?
Author(s) -
Park Andrew,
Lans Jonathan,
Raskin Kevin,
Hornicek Francis,
Schwab Joseph,
Lozano Calderon Santiago
Publication year - 2019
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25332
Subject(s) - medicine , hypoalbuminemia , odds ratio , bone sarcoma , surgery , radiation therapy , malnutrition , sarcoma , hematoma , multivariate analysis , postoperative hematoma , confidence interval , risk factor , soft tissue , pathology
Background Modifiable risk factors that can be optimized to minimize postoperative complications in patients with bone sarcomas are yet to be identified. Methods We retrospectively identified 275 patients aged 18 and older who underwent surgery for primary bone sarcomas who also had albumin values recorded within 4 weeks before surgery. Postoperative complications were defined as infection, hematoma, need for additional surgery, or wound complications. Results In the multivariate analysis, age ( P = 0.049) and neoadjuvant radiotherapy ( P = 0.008) were independently associated with postoperative complications. We then performed a subanalysis of patients without a pelvic tumor who also did not receive radiotherapy ( n = 178). In this population, albumin less than 2.8 g/dL was found to be independently associated with postoperative complications (odds ratio [OR], 4.69. 95% confidence intervals [CI], 1.03‐21.97; P = 0.046). Conclusions This study demonstrates that hypoalbuminemia (albumin < 2.8 g/dL) is associated with postoperative complications in patients with nonpelvic bone sarcomas who do not receive radiation. Future studies are necessary to further elucidate the role of nutrition, and they may show that nutritional status is a modifiable risk factor that can be optimized to improve the outcome of surgery for primary bone sarcomas.