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Prognostic value of 18 F‐FDG PET/CT parameters in patients who undergo salvage treatments for recurrent squamous cell carcinoma of the larynx and hypopharynx
Author(s) -
Lee Jae Ryung,
Almuhaimid Turki M.,
Roh JongLyel,
Oh Jungsu S.,
Kim SooJong,
Kim Jae Seung,
Choi SeungHo,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25185
Subject(s) - medicine , positron emission tomography , standardized uptake value , nuclear medicine , proportional hazards model , larynx , salvage therapy , fluorodeoxyglucose , radiology , oncology , chemotherapy , surgery
Background Recurrent laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC) is commonly associated with poor survival outcomes. We evaluated the prognostic role of 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F‐FDG PET/CT) parameters quantitatively measured in patients who underwent salvage treatments for recurrent LHSCC. Methods This study involved 100 consecutive LHSCC patients who underwent 18 F‐FDG PET/CT for recurrent staging and subsequent salvage treatments. Maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured using 18 F‐FDG PET/CT. Cox proportional hazards regression analyses were used to assess the associations between quantitative 18 F‐FDG PET/CT parameters and other clinicopathological factors with progression‐free survival (PFS) and overall survival (OS). Results Two‐year postsalvage PFS and OS rates were 67.9% and 74.3%, respectively. All 18 F‐FDG PET parameters of SUV max , MTV, and TLG were significantly associated with poor PFS and OS outcomes after salvage treatment (all P  < 0.05). Multivariate analyses revealed that recurrence site, MTV (>6.5 mL), and TLG (>17.1 g) were independent variables predictive of PFS. Karnofsky score, SUV max (>4.0), and TLG (>17.1 g) were the independent prognostic factors for OS. Conclusions 18 F‐FDG PET/CT can be useful in predicting postsalvage recurrence and survival in patients with recurrent LHSCC.

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