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Fluorescence‐guided surgery for high‐grade gliomas
Author(s) -
Lakomkin Nikita,
Hadjipanayis Constantinos G.
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25154
Subject(s) - medicine , parenchyma , food and drug administration , glioma , prodrug , resection , surgery , pathology , pharmacology , cancer research
5‐aminolevulinic acid (5‐ALA) is a prodrug that results in the fluorescence of high‐grade gliomas relative to the surrounding brain parenchyma. 5‐ALA has been increasingly utilized in fluorescence‐guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression‐free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5‐ALA, as well as emerging applications for this agent.