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Intraoperative fluorescence imaging in thoracic surgery
Author(s) -
Newton Andrew D.,
Predina Jarrod D.,
Nie Shuming,
Low Philip S.,
Singhal Sunil
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25149
Subject(s) - medicine , indocyanine green , folate receptor , mesothelioma , cardiothoracic surgery , radiology , fluorescence lifetime imaging microscopy , pathology , cancer , surgery , cancer cell , fluorescence , physics , quantum mechanics
Intraoperative fluorescence imaging (IFI) can improve real‐time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow ® ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor‐targeted near‐infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.