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Hormone receptors analysis in Chinese patients with dermatofibrosarcoma protuberans
Author(s) -
Meng Tian,
Shi Xiaohua,
Wu Shafei,
Luo Yufeng,
Wang Xiaojun,
Long Xiao
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25117
Subject(s) - dermatofibrosarcoma protuberans , immunohistochemistry , pathological , medicine , progesterone receptor , estrogen receptor , pathology , estrogen , dermatofibrosarcoma , hormone , hormone receptor , breast cancer , cancer
Background and Objectives Dermatofibrosarcoma protuberans (DFSP) is a relatively rare skin tumor. Clinical observations indicated that DFSP has a more aggressive behavior during pregnancy, which suggest there might be a hormonal influence on this tumor. We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) in DFSP patients. Methods In our present case series, patients with histopathological‐confirmed DFSP at a single institution were identified. The clinical, pathological, and immunohistochemical data were gathered for each patient. Expression of ER and PR were determined on formalin‐fixed, paraffin‐embedded tissue sections using immunohistochemistry. Some objective clinical and pathological indicators were then selected to compare between ER and PR status. Results Immunoreactivity revealed none of these tumors stained positively for ER, while eight tumors (28.6%) stained positively for PR. There was a statistically significant difference in the distribution of tumor location between the PR‐positive/negative groups. Conclusions This finding suggests that progesterone may have potential effects in growth of DFSPs. Further studies are needed to fully address this question.