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Multi‐center retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with single lymph node metastasis and extra nodal extension
Author(s) -
Hasegawa Takumi,
Yanamoto Souichi,
Otsuru Mitsunobu,
Kakei Yasumasa,
Okura Masaya,
Yamakawa Nobuhiro,
Yamada Shinichi,
Ota Yoshihide,
Umeda Masahiro,
Kirita Tadaaki,
Kurita Hiroshi,
Ueda Michihiro,
Komori Takahide
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25083
Subject(s) - medicine , oncology , lymph node , chemoradiotherapy , retrospective cohort study , single center , radiation therapy , metastasis , surgery , cancer
Background Oral squamous cell carcinoma (OSCC) containing single lymph node metastasis (pN1) with extra nodal extension (ENE) is a rare clinical situation. Therefore, it is unclear whether pN1 with ENE is at high risk of recurrence among the OSCC population, or whether postoperative radiotherapy (RT)/concomitant chemoradiotherapy (CCRT) is effective in these cases. Objectives The purpose of this retrospective study was to investigate the prognosis and compare between no postoperative therapy and postoperative RT/CCRT in pN1 with ENE OSCC patients. Methods Clinicopathological data and treatment modalities were investigated. The evaluated endpoints were overall survival (OS) and type of recurrence. Results The 3‐year cumulative OS rates for the pN1 only, multiple lymph node metastasis (MLM) only, ENE + MLM, and ENE + pN1 groups were 77.2%, 66.8%, 43.3%, and 66.6%, respectively. In the ENE + pN1 group, the most common cause of death in the surgery only group was from regional failure. The surgery + RT/CCRT group was associated with better disease‐specific survival and OS rates than the surgery only groups ( P < 0.05). Conclusions The prognosis of ENE + pN1 was not as poor as that of ENE + MLM, although both these groups feature ENE. Adjuvant therapy (RT/CCRT) after surgery is recommend for cases of ENE + pN1.