Premium
Gallbladder carcinoma: An analysis of the national cancer data base to examine hispanic influence
Author(s) -
Liu Chrissy,
Berger Nicholas G.,
Rein Lisa,
Tarima Sergey,
Clarke Callisia,
Mogal Harveshp,
Christians Kathleen K.,
Tsai Susan,
Gamblin T. Clark
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25050
Subject(s) - medicine , gallbladder cancer , ethnic group , demography , incidence (geometry) , proportional hazards model , cancer , physics , sociology , anthropology , optics
Background Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non‐Hispanic populations. Methods Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined. Results The study identified 12 952 patients. Median age was 71 years and 68.8% were female. The study characterized 69.8% White, 13.9% Black, 11.0% Hispanic, and 5.4% other patients. A 5‐year OS curves differed, with survival highest in Hispanic patients (27% vs 23% Other, 18% White, and 17% Black, P < 0.001). Hispanics presented at younger ages (67 vs 72 years, P < 0.001), were more likely to be uninsured (17.3% vs 3.9% P < 0.001), had lower income ( P < 0.001), and education levels ( P < 0.001) compared to Whites. Following multivariable modeling, treatment at an academic facility (HR 0.90, 95%CI 0.84‐0.97) and year of diagnosis (HR 0.90, 95%CI 0.88‐0.92) related to survival. Hispanic ethnicity did not show significance ( P = 0.207). Discussion Hispanic ethnicity exhibits the highest OS for GBC, but after adjusting for covariates, this influence is not significant.