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Neutrophil‐lymphocyte ratio is associated with prognosis in patients who underwent potentially curative resection for gastric cancer
Author(s) -
Szor Daniel José,
Roncon Dias Andre,
Pereira Marina A.,
Ramos Marcus F.K.P.,
Zilberstein Bruno,
Cecconello Ivan,
Ribeiro Ulysses
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25036
Subject(s) - medicine , neutrophil to lymphocyte ratio , gastroenterology , lymphadenectomy , lymph node , multivariate analysis , gastrectomy , stage (stratigraphy) , cancer , lymphocyte , risk factor , prospective cohort study , surgery , paleontology , biology
Background and Objectives The role of inflammation in cancer development is a well‐known phenomenon that may be represented by the neutrophil‐lymphocyte ratio (NLR). The present research intends to determine the impact of NLR on the survival outcome of patients with gastric cancer (GC), and to evaluate its use as a stratification factor for the staging groups. Methods Data regarding clinical characteristics, surgery, pathology, and follow‐up were retrospectively collected from our single‐center prospective database. Blood samples were obtained before surgery. Results A total of 383 patients (231 males) who underwent gastrectomy with lymphadenectomy were evaluated between 2009 and 2016. NLR established cutoff was 2.44, and patients were divided in NLR ≥2.44 (hNLR) and <2.44 (lNLR). hNLR patients (38.4% of the cases) had lower disease‐free survival and overall survival (OS) compared to lNLR patients ( P = 0.047 and P = 0.045, respectively). Risk stratification according to NLR value was done in same tumor depth (T4 and