Premium
The value of additional bevacizumab in patients with high‐risk stroma‐high colon cancer. A study within the QUASAR2 trial, an open‐label randomized phase 3 trial
Author(s) -
Huijbers Anouck,
van Pelt Gabi W.,
Kerr Rachel S.,
Johnstone Elaine C.,
Tollenaar Rob A.E.M.,
Kerr David J.,
Mesker Wilma E.
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24998
Subject(s) - stroma , medicine , bevacizumab , colorectal cancer , capecitabine , oncology , population , gastroenterology , angiogenesis inhibitor , cancer , urology , pathology , chemotherapy , immunohistochemistry , environmental health
Patients with a high stroma percentage within the primary tumor have a poor prognosis. In this study, we investigate whether anti‐angiogenic therapy might improve survival of patients with a stroma‐high profile with potentially increased angiogenesis. Materials and Methods Tissue samples of the primary tumor of 965 colon cancer patients participating in the QUASAR2 trial were analyzed for tumor‐stroma ratio (TSR). Stroma‐high (>50%) and stroma‐low (≤50%) groups were evaluated with respect to survival. Results Disease free survival (DFS) was significantly lower in the stroma‐high group (HR 1.53, 95%CI 1.19‐1.95, P = 0.001). No difference in DFS was seen with respect to treatment with capecitabine alone (CAP) or capecitabine with bevacizumab (CAPBEV) (Stroma‐high HR 1.00, 95%CI 0.69‐1.46, P = 0.996; stroma‐low HR 1.02, 95%CI 0.75‐1.41, P = 0.883). A significant difference in survival was seen comparing groups with or without vascular invasion (DFS P < 0.001). A correlation between vascular invasion and stroma‐high was seen (χ 2 ‐test P = 0.043). Discussion and Conclusions The TSR confirmed to be a strong prognosticator for disease‐free survival in a selected high‐risk patient population. No benefit was found in response to treatment with bevacizumab when stratified for TSR. TSR showed to have an additional prognostic value in patients with vascular invasion present in the primary tumor.