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Neutrophil: Lymphocyte ratio as a method of predicting complications following hepatic resection for colorectal liver metastasis
Author(s) -
McCluney Simon J.,
Giakoustidis Alexandros,
Segler Angela,
Bissel Juliane,
Valente Roberto,
Hutchins Robert R.,
Abraham Ajit T.,
Bhattacharya Satyajit,
Kocher Hemant M.
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24996
Subject(s) - medicine , retrospective cohort study , cohort , colorectal cancer , complication , gastroenterology , neutrophil to lymphocyte ratio , metastasis , area under the curve , surgery , demographics , lymphocyte , cancer , demography , sociology
Background and Objectives Approximately 30‐50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early complications by utilising the neutrophil: lymphocyte ratio (NLR). Methods We performed a retrospective cohort study of patients undergoing hepatic resection at a single institution between 2008 and 2016. Baseline demographics and complications within 30 days following surgery were recorded, with blood tests measured until day 7. Statistical analysis was performed using Mann Whitney and ROC analysis. Results One hundred eighty‐eight operations were included. 47.3% had an associated complication, of which 31.46% were major. The median NLR was 6.31 across the cohort, 5.44 for uncomplicated procedures, 7.0 for complications and 10.65 in major complications. Median NLR was the best parameter for detecting major complications versus minor complications (AUC 0.74) as opposed to lymphocytes (AUC 0.65), neutrophils (AUC 0.60), and CRP (AUC 0.60). The diagnostic ability of NLR increased further when predicting major complications versus an uncomplicated recovery (AUC 0.78), and it was the only significant parameter in the early post‐operative period on days 2, 3, and 4 (AUC 0.70, 0.72, and 0.75). Conclusions The NLR may have a role in predicting complications following hepatic resection for CLM, and with earlier detection, potentially improving outcomes.