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Prognostic factors for resected non‐small cell lung cancer in patients with type 2 diabetes mellitus
Author(s) -
Yu Woo Sik,
Lee Chang Young,
Park Seong Yong,
Suh Jee Won,
Narm Kyoung Shik,
Kim Dae Joon,
Chung Kyung Young,
Lee Jin Gu
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24989
Subject(s) - medicine , lung cancer , diabetes mellitus , type 2 diabetes mellitus , glycated hemoglobin , oncology , metformin , glycemic , hazard ratio , cancer , comorbidity , proportional hazards model , gastroenterology , type 2 diabetes , surgery , insulin , endocrinology , confidence interval
Background For diabetic patients with lung cancer, blood glucose levels and medications such as metformin and statins may influence survival. Objectives This study aimed to determine prognostic survival factors for diabetic patients with resected non‐small cell lung cancer. Patients and Methods Between January 2005 and December 2013, 301 patients with type 2 diabetes mellitus who underwent curative resection for non‐small cell lung cancer were identified and reviewed retrospectively. Results The median follow‐up period was 48 months. In multivariate analysis for lung cancer‐specific survival, older age, forced expiratory volume in 1 s (FEV1) <80% predicted, and advanced pathologic stage were significant negative prognostic factors; statin use was a positive prognostic factor (hazard ratio (HR), 0.468). In multivariate analysis for overall survival, male sex, older age, comorbidity index, and advanced pathologic stage were significant negative prognostic factors and proper glycemic control (HR, 0.621) and statin use (HR, 0.585) were positive prognostic factors. Conclusions Proper glycemic control (glycated hemoglobin A1c <7%) is recommended for diabetic patients undergoing lung cancer operations. Further studies are required to elucidate associations between type 2 diabetes mellitus and antineoplastic effects of statins and to evaluate statins as a novel adjuvant treatment for lung cancer.