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Concomitant organ resection does not improve outcomes in primary retroperitoneal well‐differentiated liposarcoma: A retrospective cohort study at a major sarcoma center
Author(s) -
Ikoma Naruhiko,
Roland Christina L.,
Torres Keila E.,
Chiang YiJu,
Wang WeiLien,
Somaiah Neeta,
Mann Gary N.,
Hunt Kelly K.,
Cormier Janice N.,
Feig Barry W.
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24951
Subject(s) - medicine , concomitant , retrospective cohort study , single center , sarcoma , liposarcoma , surgery , cohort , multivariate analysis , medical record , pathology
Background We investigated whether concomitant organ removal as part of the primary resection of RP WDLPS confers an outcome advantage in patients treated at a major sarcoma center. Methods The departmental sarcoma database was reviewed to identify patients with RP WDLPS who underwent initial surgical resection for primary disease at MD Anderson Cancer Center during the study period 1995‐2011. We retrospectively reviewed medical records and examined associations between clinicopathologic variables and overall survival (OS) as well as disease‐free survival (DFS). Results Among 83 patients included in this study, 76 patients (92%) underwent complete resection (R0/R1). Concomitant organ resections were performed in 38 patients (46%). Invasion of the resected organ/s was seen in six patients (7%). Estimated OS was 11.3 years (5‐year OS, 86%), and DFS was 5.4 years (5‐year DFS, 51%). By multivariate analysis, concomitant organ resection was not associated with improved OS ( P = 0.428) or DFS ( P = 0.946), and lack of organ resection was associated with a lower risk of postoperative complications ( P = 0.01). Conclusions Concomitant organ resection was not associated with a survival benefit in RP WDLPS in this study. In patients with primary RP WDLPS, we recommend selective resection of contiguous organs only if there is clinical suspicion of invasion.