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Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma
Author(s) -
Lewis Heather L.,
Chakedis Jeff M.,
Talbert Erin,
Haverick Ericka,
Rajasekera Priyani,
Hart Philip,
Bloomston Mark,
Dillhoff Mary,
Pawlik Timothy M.,
Guttridge Denis,
Schmidt Carl R.
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24940
Subject(s) - medicine , cytokine , perioperative , pancreatectomy , gastroenterology , prospective cohort study , adenocarcinoma , pancreas , oncology , surgery , cancer
Background Soluble signaling molecules may play an important role in malignant pathogenesis. We hypothesize that perioperative cytokine levels are associated with outcomes in patients with pancreatic adenocarcinoma (PDAC) undergoing surgical resection. Methods One hundered and eighteen patients with benign or malignant pancreatic disease were enrolled in a prospective study through a protocol for banking biologic samples. Peripheral blood was drawn at time of operation, and a multiplex cytokine assay was performed. Statistical analysis was via χ 2 and Kaplan Meier methods. Results Of 118 patients enrolled, 85 (72%) had a diagnosis of PDAC, and 60 (70%) ultimately underwent partial pancreatectomy. Cytokine levels were not associated with postoperative complications in this initial cohort. A plasma level of monocyte chemoattractant protein‐1 (MCP‐1) pg/mL ≤118 was associated with better overall survival (OS) (median survival 21 months vs 12.8 months, P = 0.023), as was non‐detectable interleukin‐8 (IL‐8) (19 months) versus detectable IL‐8 (12.8 months, P = 0.05). Patients with both MCP‐1 >118 pg/mL and detectable IL‐8 had a median survival of 10.6 months ( P = 0.028). Conclusions MCP‐1 and IL‐8 cytokine levels are associated with decreased survival following pancreatectomy for PDAC, and may be useful biomarkers. Measurement of these cytokine levels at different time points in future investigations will be important to validate these findings.