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Short‐term outcomes and risk factors for pancreatic fistula after pancreatic enucleation: A single‐center experience of 142 patients
Author(s) -
Wang Xing,
Tan Chunlu,
Zhang Hao,
Chen YongHua,
Yang Min,
Ke Nengwen,
Liu XuBao
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24804
Subject(s) - medicine , enucleation , pancreatic fistula , pancreas , pancreatitis , acute pancreatitis , surgery , pancreaticoduodenectomy , gastroenterology , radiology
Background Enucleation is increasingly used for benign or low‐grade pancreatic neoplasms. Enucleation preserves the pancreatic parenchyma as well as decreases the risk of long‐term endocrine and exocrine dysfunction, but may be associated with a higher rate of postoperative pancreatic fistula (POPF). The aim of this study was to assess short‐term outcomes, in particular, POPF. Methods Data were collected retrospectively from all 142 patients who underwent pancreatic enucleation between 2009 and 2014 in our institution were analyzed. Results Lesions were most frequently located in the head and uncinate process of the pancreas (60.6%), and the most common types were neuroendocrine neoplasms (52.1%). Overall morbidity was 66%, mainly due to POPF (53.5%), and severe morbidity was only 8.4%, including one death (0.7%). Clinical POPF (Grade B or C) occurred in 22 patients (15.5%). Independent risk factors for clinical POPF were age ≥60 years, an episode of acute pancreatitis, and cystic morphology. Tumor size, coverage, histological differentiation, and prolonged operative time were not associated with the risk of POPF. Conclusions Enucleation is a safe and feasible procedure for benign or low‐grade pancreatic neoplasms. The rate of clinical POPF is acceptable, and clinical POPF occurs more frequently in elderly patients (≥60 years of age), patients with cystic neoplasms, or patients with an episode of acute pancreatitis.