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Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients
Author(s) -
Handa Tadashi,
Katayama Ayaka,
Yokobori Takehiko,
Yamane Arito,
Horiguchi Jun,
KawabataIwakawa Reika,
Rokudai Susumu,
Bao Pinjie,
Gombodorj Navchaa,
Altan Bolag,
Kaira Kyoichi,
Asao Takayuki,
Kuwano Hiroyuki,
Nishiyama Masahiko,
Oyama Tetsunari
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24705
Subject(s) - medicine , breast cancer , triple negative breast cancer , phenotype , cancer stem cell , oncology , cancer , ca15 3 , cancer research , pathology , gene , genetics , biology
Background and Objectives The Caspase14 (CASP14) was reported that the low expression of CASP14 in ovarian cancer and colon cancer was associated with cancer progression, on the other hand, that the CASP14 expression in breast cancer was higher than that of non‐cancerous tissues. The purpose of this study is to determine the clinical significance of CASP14 in breast cancer. Methods We performed immunohistochemistry for CASP14, ER, PgR, HER2, Ki67, EGFR, CK5/6, CD44, CD24, ALDH1, claudins, and androgen receptor in 222 breast cancer patients including 55 TNBC cases, and evaluated the relationship of CASP14, above‐mentioned markers, and prognosis. Using public microarray database of breast cancer, the prognostic value of CASP14 was calculated. Results High CASP14 expression was significantly associated with TNBC subtype ( P = 0.015), nuclear grade ( P = 0.006), Ki67, EGFR ( P < 0.001, P = 0.016), ALDH1, CD44 and CD24 ( P < 0.001, P < 0.001, P = 0.001) in 222 breast cancer cases, and the high expression of claudin1 ( P = 0.017), and androgen receptor ( P = 0.002) in TNBC cases was related to the high CASP14. According to the public database, survival in the high CASP14 breast cancer patients was shorter than low CASP14 patients. Conclusions High CASP14 expression is a marker of breast cancer aggressiveness in association with proliferation, TNBC phenotype, and cancer stemness.