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Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study
Author(s) -
Jiang Ke,
Lei Jianyong,
Li Canjun,
Shu Kunpeng,
Li Wenbin,
Zhang Yuwei,
Li Zhihui,
Gong Rixiang,
Zhu Jingqiang
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24683
Subject(s) - medicine , receiver operating characteristic , gastroenterology , thyroid carcinoma , area under the curve , proportional hazards model , oncology , lymph node , medullary cavity , lymphocyte , neutrophil to lymphocyte ratio , fibrinogen , survival analysis , thyroid
Background The significance of inflammation based scores including the neutrophil‐to‐lymphocyte ratio (NLR), derived neutrophil‐to‐lymphocyte ratio (dNLR), platelet‐to‐lymphocyte ratio (PLR), lymphocyte‐to‐monocyte ratio (LMR), prognostic nutritional index (PNI), and plasma fibrinogen remains unclear in medullary thyroid carcinoma (MTC). We aimed to compare the prognostic value of these scores. Methods Seventy‐eight patients newly diagnosed as MTC with operation in our institution from May 2009 to September 2016 were retrospectively evaluated. Receiver operating characteristic (ROC) curves and Kaplan‐Meier analyses were calculated to compare the prognostic value of these scores. Results Increased PLR was predictive of lymph node metastasis (AUC = 0.644, P = 0.022), capsule invasion (AUC = 0.666, P = 0.007), advanced tumor stages (AUC = 0.657, P = 0.011), and recurrence (AUC = 0.655, P = 0.049). Increased fibrinogen was predictive of lymph node metastasis (AUC = 0.669, P = 0.006) and capsule invasion (AUC = 0.631, P = 0.038). Reduced PNI was predictive of recurrence (AUC = 0.655, P = 0.049). Kaplan‐Meier analyses and Cox regression analysis revealed that PLR was a significant predictor for recurrence. Conclusions PLR, fibrinogen, and PNI are all predictive. Specially, PLR is superior to other inflammation based scores in terms of prognostic ability.