Premium
Diagnostic and prognostic role of SF1, IGF2, Ki67, p53, adiponectin, and leptin receptors in human adrenal cortical tumors
Author(s) -
Babińska Anna,
Pęksa Rafał,
Wiśniewski Piotr,
ŚwiątkowskaStodulska Renata,
Sworczak Krzysztof
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24665
Subject(s) - leptin , medicine , adiponectin , receptor , endocrinology , cancer research , obesity , insulin resistance
Background The authors have examined the immunohistochemical expression of several proteins and their relationship with adrenal cortical carcinoma (ACC) diagnosis and progression. Materials and Methods A total of 83 patients with benign and malignant adrenal cortex tumors operated on in a single center were included in the study. Expression of the following proteins was examined: steroidogenic factor 1 (SF1), insulin growth factor 2 (IGF2), Ki67, p53, as well as adiponectin (Adipo R1, Adipo R2), and leptin (Ob‐R) receptors. Results Multivariate analysis revealed that the expression of SF1, IGF2, and Adipo R1 and R2 receptors was associated with ACC diagnosis. An acknowledged proliferation marker Ki67 was related with the size of ACC and was an independent ACC diagnosis marker. The authors also assessed the relationship between immunohistochemical parameters and overall survival (OS) and disease progression. Only high IGF2 expression was associated with longer OS ( P = 0.025). The most significant one for the prognosis of ACC patients was tumor resectability of the primary tumor. More favorable prognosis was found for young men ( P = 0.033). Conclusions The presented data indicate that immunohistochemical assessment (of IGF2, SF1, Adipo R1, and R2 receptors’ expression) may be useful in making the diagnosis of uncertain ACC cases.