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Does surgery or radiation provide the best overall survival in Ewing's sarcoma? A review of the National Cancer Data Base
Author(s) -
Miller Benjamin J.,
Gao Yubo,
Duchman Kyle R.
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24652
Subject(s) - medicine , sarcoma , ewing's sarcoma , proportional hazards model , surgery , cancer , multivariate analysis , survival analysis , overall survival , radiation therapy , oncology , pathology
Background and Objectives There is continuing debate regarding the ideal modality for local control of the primary tumor for patients with Ewing's sarcoma. The primary aim of this study is to investigate the impact of the method of local control on overall survival in patients with Ewing's sarcoma. Methods The National Cancer Data Base was used to identify patients <40 years of age with high‐grade Ewing's sarcoma of bone. A Kaplan‐Meier survival analysis was performed at 2, 5, and 10 years. Factors with a level of significance of P < 0.1 at the 5‐year time point were included in a multivariate Cox proportional hazards model. Results Diminished 5‐year survival was noted for patients with metastatic disease, local control with radiation alone, age ≥18 years, tumor size >8 cm, and male sex while controlling for tumor site. Surgery alone was consistently the method of local control that resulted in the highest overall survival. Conclusions Surgery alone resulted in the best overall survival for patients with Ewing's sarcoma of bone. The results of this investigation provide support to the approach of surgical resection with negative margins when possible.