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Urological complications after cystectomy as part of pelvic exenteration are higher than that after cystectomy for primary bladder malignancy
Author(s) -
Brown Kilian G.M.,
Solomon Michael J.,
Latif Edward R.,
Koh Cherry E.,
Vasilaras Arthur,
Eisinger David,
Sved Paul
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24511
Subject(s) - cystectomy , medicine , urinary diversion , malignancy , pelvic exenteration , urinary system , surgery , urology , bladder cancer , cancer
Background Total cystectomy and subsequent reconstruction of the urinary tract may be required for primary malignancy of the bladder, or in the context of multi‐visceral resection for more advanced pelvic tumors. Complications following urinary diversion are a major source of morbidity, particularly in pelvic exenteration (PE) patients. Methods All patients who underwent radical cystectomy alone or during PE at a single tertiary referral centre between 2008 and 2014 were reviewed. Postoperative urological complications were collected and compared between groups. Results Two hundred and thirty‐one patients underwent en bloc cystectomy (98 cystectomy alone, 133 as part of a PE). Postoperative urological complications occurred in 33% of the cystectomy alone group and 59% of the PE group ( P < 0.001). PE for recurrence had higher complications than PE for primary malignancy (67% vs. 48%, P = 0.035). Urological leaks occurred in 3%, 6%, and 14% of patient who had cystectomy alone, PE for primary malignancy and PE for recurrence. Major blood loss and previous pelvic radiotherapy independently predicted conduit‐associated complications in PE patients ( P = 0.002 and 0.035). Conclusions Urological complications of cystectomy, particularly urine leaks and sepsis, are more common in patients undergoing PE compared to those with cystectomy alone. Prior pelvic radiotherapy, the extent of surgical resection and major blood loss may contribute to urological morbidity. J. Surg. Oncol. 2017;115:307–311 . © 2016 Wiley Periodicals, Inc.