Premium
The effect of surgery type on survival and recurrence in very young women with breast cancer
Author(s) -
Quan May Lynn,
Paszat Lawrence Frank,
Fernandes Kimberly A.,
Sutradhar Rinku,
McCready David R.,
Rakovitch Eileen,
Warner Ellen,
Wright Frances C.,
Hodgson Nicole,
Brackstone Muriel,
Baxter Nancy N.
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24489
Subject(s) - medicine , mastectomy , breast cancer , cohort , proportional hazards model , cancer registry , surgery , radiation therapy , cancer , confounding , breast conserving surgery , population , cohort study , environmental health
Background The impact of surgical treatment on outcomes in breast cacner in very young women remains unclear. We sought to determine the effect of surgery type on risk of recurrence and survival in a population‐based cohort. Methods All women diagnosed with breast cancer aged ≤35 (1994–2003) were identified from the Ontario Cancer Registry. Patient, tumor, and treatment variables, including primary surgery, recurrences, and death were abstracted from chart review. Cox regression models were fit to determine the effect of surgery type on recurrence and overall survival. Results We identified 1,381 patients with 11‐year median follow‐up of which 793 (57%) had BCS. Of the remaining mastectomy patients, 52% had postmastectomy radiation. Overall, 41% of patients sustained a recurrence of any type and 31% died. Controlling for known confounders, there was no association between type of surgery and death from any cause (HR = 0.98, 95% CI = 0.78, 1.25) or first recurrence (HR = 0.93, 95% CI = 0.75, 1.14). Distant recurrence was most common (13% in BCS; 25.3% in mastectomy) with local recurrence 12.4% after BCS and 7.5% after mastectomy. Conclusions In this cohort of very young women who were selected for treatment with BCS and mastectomy, we found similar oncologic outcomes. J. Surg. Oncol. 2017;115:122–130 . © 2017 Wiley Periodicals, Inc.