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Surgical excision margin for primary acral melanoma
Author(s) -
Lee KyeongTae,
Kim EunJi,
Lee DongYoun,
Kim JungHan,
Jang KeeTaek,
Mun GooHyun
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24442
Subject(s) - medicine , margin (machine learning) , retrospective cohort study , melanoma , surgery , surgical margin , multivariate analysis , overall survival , resection , cancer research , machine learning , computer science
Background and Objectives This study aimed to evaluate treatment outcomes of acral melanoma (AM) based on the excision margin. Methods A retrospective cohort study was conducted for patients with primary AM, analyzing recurrence rates, local and in‐transit recurrence‐free survival (LITRFS), disease‐free survival (DFS), and melanoma‐specific survival (MSS). Results Data from 129 patients of AM were analyzed. In 53 patients with thin AM (thickness ≤1 mm), neither recurrence nor mortality occurred regardless of whether the excision margin was >1 cm or not. Seventy‐six patients had thick AM (thickness >1 mm), including 36 treated with a <2 cm excision margin and 40 with a 2 cm margin. Multivariate analyses revealed that a 2 cm margin was associated with a reduced rate of local recurrence (HR, 0.120; P ‐value = 0.023) and LITR (HR, 0.187; P ‐value = 0.013) compared with a <2 cm margin. DFS and MSS did not differ between the two groups. Conclusions Thin AM were successfully treated with a 1 cm excision margin. For thick AM, a 2 cm excision margin provided improved local control, compared with a <2 cm margin; however, this benefit did not translate into a survival gain. J. Surg. Oncol. 2016;114:933–939 . © 2016 Wiley Periodicals, Inc.