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Association between age and overall survival of patients with hepatocellular carcinoma after hepatic resection
Author(s) -
Tan JunTao,
Zhao Chang,
Peng NingFu,
Yang Yang,
Zhong JianHong,
Yang Tian,
Zheng MingHua,
Wang YanYan,
Gong WenFeng,
Xiang BangDe,
Li LeQun
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24434
Subject(s) - medicine , hepatocellular carcinoma , hepatectomy , gastroenterology , resection , multivariate analysis , liver function , surgery
Aim The suitability of hepatic resection for older patients remains controversial. This study aimed to investigate whether age influences overall survival of patients with hepatocellular carcinoma (HCC) after resection. Methods Records of 1,132 patients with HCC after hepatic resection were retrospectively reviewed. Overall survival (OS) was compared between younger and older patients based on five cut‐off ages (30, 40, 50, 60, and 70 years). Results Across all patients, OS was 89.7% at 1 year, 67.7% at 3 years, and 47.7% at 5 years. OS was similar between younger and older patients at all cut‐off ages (all P > 0.1), but OS was marginally lower among patients >70 years old than those ≤70 ( P = 0.090). Multivariate analyses identified several risk factors for lower OS: preoperative serum albumin <35 g/L, alanine aminotransferase >80 U/L, α‐fetoprotein ≥400 ng/ml, presence of esophagogastric varices or macrovascular invasion, incomplete/absent tumor capsule, tumor size >10 cm, tumor number ≥3, and major hepatectomy. Conclusion Age does not influence the prognosis of patients with HCC after hepatic resection. Older patients should be considered for curative resection if remnant liver volume and liver function are adequate. J. Surg. Oncol. 2016;114:966–970 . © 2016 Wiley Periodicals, Inc.