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Health‐related quality of life following treatment for extremity soft tissue sarcoma
Author(s) -
Davidson Darin,
Barr Ronald D.,
Riad Soha,
Griffin Anthony M.,
Chung Peter W.,
Catton Charles N.,
O'Sullivan Brian,
Ferguson Peter C.,
Davis Aileen M.,
Wunder Jay S.
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24424
Subject(s) - medicine , quality of life (healthcare) , eq 5d , soft tissue sarcoma , anxiety , physical therapy , minimal clinically important difference , depression (economics) , health related quality of life , soft tissue , sarcoma , surgery , disease , randomized controlled trial , pathology , psychiatry , nursing , economics , macroeconomics
Background and Objectives The primary objective of this study was to estimate the change in health‐related quality of life (HRQL) 1 year following treatment for extremity soft tissue sarcoma (STS), measured by the EQ‐5D. Secondary objectives included determining clinical variables associated with HRQL at 1 year, estimating the proportion with a clinically important difference (CID) in HRQL, and evaluating variability within EQ‐5D domains. Methods Patients over the age of 16 years, treated for a localized extremity STS, were included. The EQ‐5D change score from pre‐treatment to 1‐year follow‐up was determined. The association of clinical variables with EQ‐5D scores was estimated using a linear regression model. The proportion of patients with a CID in HRQL score was determined. A vector analysis of the EQ‐5D domains was undertaken. Results The mean EQ‐5D change score was 0.02. Age, sex, disease status, and initial EQ‐5D score were associated with EQ‐5D score at 1 year. There was a CID improvement in 32% and a deterioration in 24%. The anxiety and depression domain demonstrated the most change between baseline and 1 year after treatment. Conclusion Most patients maintain a high level of HRQL following treatment for extremity STS. J. Surg. Oncol. 2016;114:821–827 . © 2016 2016 Wiley Periodicals, Inc.