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Survival rates in T1 and T2 gastric cancer: A Western report
Author(s) -
Ikoma Naruhiko,
Blum Mariela,
Chiang YiJu,
Estrella Jeannelyn S.,
RoyChowdhuri Sinchita,
Fournier Keith,
Mansfield Paul,
Ajani Jaffer A.,
Badgwell Brian D.
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24382
Subject(s) - medicine , hazard ratio , stage (stratigraphy) , gastrectomy , confidence interval , cancer , univariate analysis , multivariate analysis , gastroenterology , gastric adenocarcinoma , population , adenocarcinoma , oncology , surgery , paleontology , environmental health , biology
Background and Objectives The purpose of this study was to identify clinicopathologic factors associated with overall survival (OS) in early T stage gastric cancer in a Western population. Methods Patients with stage T1 or T2 gastric or gastroesophageal adenocarcinoma who had undergone upfront gastrectomy from 1995 to 2013 were identified in an institutional database. Results We identified 121 patients with pathologic stage T1 or T2 tumors (49 [41%] T1a; 49 [41%] T1b; and 23 [19%] T2) who underwent R0 resection without preoperative treatment. Of these, 53% were white, 9% African American, 17% Hispanic, and 22% Asian. The median follow‐up was 5.7 years, and the 5‐year OS rate was 89% (98%, 93%, and 66% for patients with T1a, T1b, and T2 tumors, respectively). Univariate analysis revealed a higher risk of death in patients with T2 tumors and those of African American race. On multivariate analysis, T2 stage was the only variable independently associated with OS (hazard ratio, 2.80; 95% confidence interval, 1.11–7.12; P = 0.03). Conclusion In this study of a Western population of patients with T1 or T2 gastric cancer, T2 stage was associated with diminished OS, whereas nodal status and race were not. J. Surg. Oncol. 2016;114:602–606 . © 2016 Wiley Periodicals, Inc.