Premium
Patterns of major wound complications following multidisciplinary therapy for lower extremity soft tissue sarcoma
Author(s) -
Miller Eric D.,
Mo Xiaokui,
Andonian Nicole T.,
Haglund Karl E.,
Martin Douglas D.,
Liebner David A.,
Chen James L.,
Iwenofu Obiajulu H.,
Chakravarti Arnab,
Scharschmidt Thomas J.,
Mayerson Joel L.,
Pollock Raphael E.,
XuWelliver Meng
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24313
Subject(s) - medicine , seroma , surgery , soft tissue sarcoma , soft tissue , sarcoma , radiation therapy , hematoma , multivariate analysis , complication , pathology
Background and Objectives The purpose of this study was to determine the pattern and timing of major wound complications (MWCs) in patients at our institution who received multimodality treatment for lower extremity soft tissue sarcoma (LE‐STS) and to evaluate the impact of MWCs on tumor control and patient outcomes. Methods The medical records of 102 LE‐STS patients treated with limb‐sparing surgery and radiation therapy were reviewed. MWCs were defined as secondary operations with anesthesia, seroma/hematoma aspiration, admission for IV antibiotics, or persistent deep packing. Results MWCs occurred in 22% of patients, with 45% of events occurring >120 days after resection. On multivariate analysis, preoperative external beam radiation therapy (EBRT) (OR 4.29, 95% CI 1.06–17.40, P = 0.042) and skin graft placement (OR 6.39, 95% CI 1.37–29.84, P = 0.018) were found to be independent predictors of MWCs. MWC occurrence did not predict for chronic toxicity and did not impact tumor control or survival. Conclusions A considerable proportion of MWCs occur >120 days from surgical resection with preoperative EBRT and skin graft placement independent predictors for MWCs. While an additional source of morbidity, MWC occurrence did not impact tumor control, nor did it predict for chronic toxicity. J. Surg. Oncol. 2016;114:385–391 . © 2016 Wiley Periodicals, Inc.