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Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases
Author(s) -
Masai Kyohei,
Sakurai Hiroyuki,
Suzuki Shigeki,
Asakura Keisuke,
Nakagawa Kazuo,
Watanabe ShunIchi
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24302
Subject(s) - medicine , adenocarcinoma , lymph node , dissection (medical) , lung , asymptomatic , lung cancer , positron emission tomography , radiology , metastasis , fluorodeoxyglucose , nodule (geology) , pathology , cancer , paleontology , biology
Objectives Colloid adenocarcinoma of the lung (CA) is a rare neoplasm that is associated with abundant mucin, which destroys alveoli. We evaluated the clinicopathological features of CA. Methods A total of 4,648 patients underwent surgical resection of primary lung cancer at our institution from 2002 to 2014. We analyzed the clinicopathological features of CA in six (0.13%) of these patients. Results All patients were asymptomatic. The median age was 60.5 years. The median tumor size was 2.4 cm. All tumors appeared as solitary solid nodules on computed tomography (CT). Four of the six showed intense 18 F‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG–PET) accumulation, and the remaining two showed weak 18 F‐FDG accumulation. All patients underwent lobectomy with systematic lymph node dissection. Histologically, CAs presented with various degrees of a non‐mucinous component in addition to abundant mucin. Only one patient with pN2 had recurrence. Conclusions On CT, CA appears a solitary solid nodule. Further, FDG–PET findings present various 18 F‐FDG accumulations. Lobectomy with systematic lymph node dissection is an appropriate procedure in view of lymph node metastasis. Since the definitive diagnosis of CA of the lung is difficult, further immunohistochemical and genetic analyses are needed. J. Surg. Oncol. 2016;114:211–215 . © 2016 Wiley Periodicals, Inc.