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Surgical margin does not influence recurrence rate in pT1 clear cell renal cell carcinoma after partial nephrectomy: A multicenter study
Author(s) -
Kang Ho Won,
Lee Sang Keun,
Kim Won Tae,
Yun Seok Joong,
Lee SangCheol,
Kim WunJae,
Hwang Eu Chang,
Kang Seok Ho,
Hong SungHoo,
Chung Jinsoo,
Kwon Tae Gyun,
Kim Hyeon Hoe,
Kwak Cheol,
Byun SeokSoo,
Kim YongJune
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24259
Subject(s) - medicine , nephrectomy , renal cell carcinoma , pathological , surgical margin , demographics , cohort , margin (machine learning) , clear cell , clear cell renal cell carcinoma , stage (stratigraphy) , retrospective cohort study , urology , surgery , carcinoma , resection , oncology , kidney , paleontology , demography , machine learning , sociology , computer science , biology
Purpose To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN). Materials and Methods Patients (1,831) with pathologically confirmed stage T1 clear cell RCC were retrospectively analyzed following PN at eight institutions in Korea between 1999 and 2011. Demographics, operative data, pathological margin status, and site of recurrence were analyzed. Results Resection margins were positive in 31 patients (1.7% of the cohort) on final pathology. None of the clinicopathological parameters were significantly related to the marginal status (all P > 0.05). During a median follow‐up of 32.5 months, local recurrences were observed in 0.4% of negative surgical margins. There was no local recurrence in any of the cases with PSM. Distant recurrences developed in 1.7% of negative surgical margins and 3.2% of PSM. There were no significant differences in recurrence‐free survival by margin status ( P = 0.566). Conclusions Our multi‐institutional data suggest that marginal status does not influence tumor recurrence risk in pT1 clear cell RCC after PN. Careful surveillance seems to be a sufficient strategy in this clinical scenario. J. Surg. Oncol. 2016;114:70–74 . © 2016 Wiley Periodicals, Inc.