Premium
Soft tissue myxofibrosarcoma: A clinico‐pathological analysis of a series of 75 patients with emphasis on the epithelioid variant
Author(s) -
Scoccianti Guido,
Ranucci Valentina,
Frenos Filippo,
Greto Daniela,
Beltrami Giovanni,
Capanna Rodolfo,
Franchi Alessandro
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24250
Subject(s) - myxofibrosarcoma , medicine , soft tissue , pathological , epithelioid sarcoma , radiation therapy , soft tissue sarcoma , survival analysis , surgery , radiology
Background and Objectives The clinical course of soft tissue myxofibrosarcoma is characterized by a high incidence of recurrences and there is no agreement on how to identify patients at major risk. An epithelioid histological variant has been described, with a possible worse prognosis. We reviewed our series to identify prognostic factors and assess clinical significance of the epithelioid variant. Methods We examined the clinico‐pathological features of a series of 75 patients affected by soft tissue myxofibrosarcoma at a mean follow‐up of 63 months (range 17–132). Results Disease specific survival and local recurrence free survival were, respectively, 84.8% and 76.8% at 5 years. Seven patients (8.6%) presented with the epithelioid variant with a survival of 62.5%. High grade and epithelioid morphology were negative prognostic factors for patient survival, high grade, and inadequate surgical margins for local recurrence. Radiotherapy had a local protective effect in high grade tumors. Conclusions Our experience confirms the difficulties in obtaining wide margins in myxofibrosarcoma and the high rate of recurrence. Local recurrences did not significantly affect survival and a limb‐sparing approach can be chosen also in recurrences. Patients affected by the epithelioid variant showed a worse prognosis. Chemotherapy should be considered as adjuvant treatment in this subtype. J. Surg. Oncol. 2016;114:50–55 . © 2016 Wiley Periodicals, Inc.