Premium
Matrix metalloproteinase‐11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas
Author(s) -
Li WeiMing,
Wei YuChing,
Huang ChunNung,
Ke HungLung,
Li ChingChia,
Yeh HsinChih,
Chang LinLi,
Huang ChunHsiung,
Li ChienFeng,
Wu WenJeng
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24195
Subject(s) - medicine , hazard ratio , proportional hazards model , metastasis , immunohistochemistry , oncology , perineural invasion , multivariate analysis , cancer , urinary system , univariate analysis , stage (stratigraphy) , pathology , confidence interval , biology , paleontology
Background and Objectives Urothelial carcinomas (UC) of urinary bladder (UB) and upper urinary tract (UT) are heterogeneous diseases with high morbidity and mortality. We looked for genes with metalloendopeptidase activity in a published UBUC transcriptomic database (GSE31684): MMP‐11 was the most significant, showing stepwise up‐regulation. We analyzed MMP‐11 expression and association with clinicopathologic factors and survival in our well‐characterized cohort of UCs. Methods We determined MMP‐11 expression in 295 UBUCs and 340 UTUCs with immunohistochemistry, evaluated by H‐score. In a retrospective study, MMP‐11 expression was correlated with clinicopathologic features and with disease‐specific survival (DSS) and metastasis‐free survival (MeFS). The statistical significance was evaluated with univariate and multivariate analyses. Results High MMP‐11 expression was significantly associated with advanced pT status, nodal metastasis, high histological grade, vascular and perineural invasion, and frequent mitoses. In multivariate Cox regression analyses, which adjusted for standard clinicopathologic characteristics, MMP‐11 expression was independently associated with cancer‐specific mortality (hazard ratio [HR] in UTUC:3.027, P = 0.005; in UBUC: 2.631, P = 0.010) and with metastasis development (HR in UTUC:2.261, P = 0.018; in UBUC:1.801, P = 0.026). Conclusions MMP‐11 overexpression is associated with aggressive tumor phenotype and unfavorable clinical outcome in UTUC and UBUC, suggesting it may serve as a novel prognostic and therapeutic target. J. Surg. Oncol. 2016;113:700–707 . © 2016 Wiley Periodicals, Inc.