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Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test
Author(s) -
Tomimaru Yoshito,
Eguchi Hidetoshi,
Gotoh Kunihito,
Kawamoto Koichi,
Wada Hiroshi,
Asaoka Tadafumi,
Noda Takehiro,
Yamada Daisaku,
Ogawa Hisataka,
Umeshita Koji,
Nagano Hiroaki,
Doki Yuichiro,
Mori Masaki
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24166
Subject(s) - indocyanine green , medicine , hepatocellular carcinoma , platelet , liver failure , gastroenterology , liver function , hepatectomy , logistic regression , multivariate analysis , subgroup analysis , surgery , resection , meta analysis
Background and Objectives Preoperatively evaluating reserved liver function is critical in preventing posthepatectomy liver failure (PHLF) in patients undergoing liver resection. The commonly used indocyanine green (ICG) clearance test has several drawbacks. Patients would benefit from a more reliable and straightforward means of assessing the risk of PHLF. Methods This study included 277 patients with hepatocellular carcinoma (HCC) undergoing liver resection. The predictive value of known risk factors for PHLF was compared to that of ICG. Results PHLF was identified in 25 out of 277 patients (9.0%). Multivariate logistic regression analysis for identifying predictors for the PHLF development revealed platelet count and resected liver volume as significant independent predictors. In a subgroup analysis based on resected liver volume, platelet count was significantly correlated with PHLF in both larger volume (≥100 g) and smaller volume resection groups (<100 g), although ICG R15 level was associated with PHLF only in larger volume group. Conclusions Platelet count is superior to ICG R15 level in predicting PHLF development in HCC patients. J. Surg. Oncol. 2016;113:565–569 . © 2016 Wiley Periodicals, Inc.