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S‐1 plus nab ‐paclitaxel is a promising regimen for pancreatic cancer in a preclinical model
Author(s) -
Suenaga Masaya,
Yamada Suguru,
Fujii Tsutomu,
Tanaka Chie,
Kanda Mitsuro,
Nakayama Goro,
Sugimoto Hiroyuki,
Koike Masahiko,
Fujiwara Michitaka,
Kodera Yasuhiro
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24147
Subject(s) - paclitaxel , medicine , pancreatic cancer , tolerability , combination therapy , in vivo , stromal cell , angiogenesis , pharmacology , nab paclitaxel , regimen , cancer , oncology , cancer research , adverse effect , biology , microbiology and biotechnology
Objectives The aim of this study was to investigate the efficacy and mechanism of action of combined S‐1 and nab ‐paclitaxel in pancreatic cancer. Methods Three human pancreatic cancer cell lines were treated with S‐1, nab ‐paclitaxel, alone or in combination. Mice bearing subcutaneous xenograft of the cell line, PANC‐1, were treated with the same drugs. Results The growth‐inhibitory effect of combined S‐1 and nab ‐paclitaxel was greater than that of the individual drugs, and the combination index value indicated that S‐1 and nab ‐paclitaxel had a synergistic effect in vitro. The combination of S‐1 and nab ‐paclitaxel showed greater efficacy in vivo than monotherapy, and the growth‐inhibitory effect was significantly greater when compared with the controls ( P = 0.009), although no significant reduction in body weight was observed. Fractional tumor volume analysis indicated that the combination had a synergistic effect. Tumor stroma staining with α‐smooth muscle actin was significantly decreased by nab‐ paclitaxel ( P < 0.001) while the number of CD31‐stained microvessel lumina was significantly increased by the combination therapy when compared with the control ( P = 0.046). Conclusions S‐1 and nab ‐paclitaxel had a synergetic effect in preclinical studies with good tolerability, and may play a role in stromal depletion and tumor angiogenesis. J. Surg. Oncol. 2016;113:413–419 . © 2016 Wiley Periodicals, Inc.