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Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients
Author(s) -
Su TingShi,
Liang Ping,
Lu HuanZhen,
Liang Jian,
Gao YingChuan,
Zhou Ying,
Huang Yong,
Tang MinYang,
Liang JianNing
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24128
Subject(s) - medicine , hepatocellular carcinoma , ablative case , radiation therapy , percutaneous , percutaneous ethanol injection , multivariate analysis , nuclear medicine , radiology , oncology , gastroenterology , radiofrequency ablation , ablation
Aim To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. Methods From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Class A or B; unfeasible, difficult or refusal to undergo other surgery or percutaneous ablative therapies; and tumor recurrence after other local treatment. The dose of 42–46 Gy in 3–5 fractions and 28–30 Gy in 1 fraction was prescribed. Results Of the treated patients, 114 were classified as CTP A and 18 as CTP B. Median tumor size was range 1.1–5.0 cm. The local control rate at 1 years was 90.9%. OS at 1, 3, and 5 years was 94.1%, 73.5%, and 64.3%, respectively. PFS at 1, 3, and 5 years was 82.7%, 58.3%, and 36.4%, respectively. Hepatic toxicity grade ≥3 was observed in 11 patients. Multivariate analysis revealed that CTP B was associated with worse OS ( P < 0.001) and multiple nodules were associated with worse PFS ( P = 0.001). Conclusions SBRT is a promising alternative treatment for patients with primary or recurrent small HCC who are unsuitable for surgical resection or local ablative therapy. J. Surg. Oncol. 2016;113:181–187 . © 2015 Wiley Periodicals, Inc.