Premium
Postoperative complications and overall survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
Author(s) -
Pugalenthi Amudhan,
Protic Mladjan,
Gonen Mithat,
Kingham T. Peter,
Angelica Michael I.D’.,
Dematteo Ronald P.,
Fong Yuman,
Jarnagin William R.,
Allen Peter J.
Publication year - 2016
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24125
Subject(s) - medicine , pancreaticoduodenectomy , pancreatic fistula , surgery , proportional hazards model , multivariate analysis , univariate analysis , survival rate , adenocarcinoma , survival analysis , complication , prospective cohort study , gastroenterology , pancreas , cancer , resection
Pancreaticoduodenectomy (PD) performed for pancreatic ductal adenocarcinoma (PDA) has a postoperative morbidity of 40–50%. In this study, we analyzed the impact of high grade complications after PD for PDA on overall survival. Methods A total of 596 patients that underwent PD for PDA between 2001 and 2009 were identified from a prospective database. Complications were defined and graded (1–5) as per our Institutional Surgical Secondary Events Program. High grade complications were defined as ≥grade 3. Postoperative mortality (≤90 days) was excluded. Univariate and multivariate analyses were performed to identify factors associated with overall survival. Results Median survival was 24 months. Overall complication rate was 51% (301/596). Low grade complications were recorded in 266 patients (45%) and high grade complications in 22% (n = 129). Our 90 day mortality was 3.7% (n = 22). Anastomotic fistula/leak/abscess rate was 14% (n = 82). Multivariate Cox‐Regression analysis identified node positivity, estimated blood loss (EBL) >600 ml, length of stay (LOS) >10 days, margin positivity, and vascular procedures as predictors of decreased overall survival ( P < 0.05). High grade complications were not associated with overall survival ( P = 0.948). Conclusion In this study, the occurrence of high grade postoperative complications was not associated with overall survival. J. Surg. Oncol. 2016;113:188–193 . © 2015 Wiley Periodicals, Inc.