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Neoadjuvant use of ipilimumab in locally advanced melanoma
Author(s) -
Howie Lynn J.,
Tyler Douglas S.,
Salama April K. S.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24079
Subject(s) - medicine , ipilimumab , melanoma , neoadjuvant therapy , oncology , surgery , resection , immunotherapy , cancer , cancer research , breast cancer
Recent advances in immune modulating therapies show great promise for patients with advanced melanoma, however optimal strategies for achieving long‐term disease control in locally advanced melanoma are unclear. We present two cases of neoadjuvant ipilimumab, one case in combination with isolated limb infusion (ILI) followed by surgical resection and one followed by surgery alone. Both patients have had durable responses. These cases highlight the ongoing need for prospective trials in the neoadjuvant setting. J. Surg. Oncol. 2015;112:841–843 . © 2015 Wiley Periodicals, Inc.