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Are preoperative blood neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios useful in predicting malignancy in surgically‐treated mucin‐producing pancreatic cystic neoplasms?
Author(s) -
Goh Brian K. P.,
Tan Damien M. Y.,
Chan ChungYip,
Lee SerYee,
Lee Victor T. W.,
Thng ChoonHua,
Low Albert S. C.,
Tai David W. M.,
Cheow PengChung,
Chow Pierce K. H.,
Ooi London L. P. J.,
Chung Alexander Y. F.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23997
Subject(s) - medicine , malignancy , pancreatic duct , gastroenterology , dysplasia , lymphocyte , jaundice , univariate analysis , pathology , pancreas , multivariate analysis
The aim of this study was to determine if neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) were predictive of malignancy in mucin‐producing pancreatic cystic neoplasms (MpPCN). Methods One hundred and twenty patients with MpPCN were retrospectively reviewed. Malignant neoplasms were defined as neoplasms harbouring invasive carcinoma or high grade dysplasia. A high NLR and PLR were defined as ≥2.551 and ≥208.1, respectively. Results High NLR was significantly associated with symptomatic tumors, larger tumors, solid component, main‐duct IPMN, and Sendai high risk category. High PLR was significantly associated with jaundice and Sendai high risk category. On univariate analyses, symptomatic tumors, jaundice, solid component, dilated pancreatic duct, and both a high NLR and PLR were significant predictors of malignant and invasive MpPCN. On multivariate analyses, solid component and dilated pancreatic duct were independent predictors of malignant and invasive MpPCN. PLR was an independent predictor for invasive MpPCN. When MpPCN were stratified by the Fukuoka and Sendai Guidelines, both a high NLR and PLR were significantly associated with malignant neoplasms within the high risk categories. Conclusions PLR is an independent predictor of invasive carcinoma. The addition of PLR as a criterion to the FCG and SCG significantly improved the predictive value of these guidelines in detecting invasive neoplasms. J. Surg. Oncol. 2015; 112:366–371 . © 2015 Wiley Periodicals, Inc.