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Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma
Author(s) -
Lane Whitney O.,
Cramer Christina K.,
Nussbaum Daniel P.,
Speicher Paul J.,
Gulack Brian C.,
Czito Brian G.,
Kirsch David G.,
Tyler Douglas S.,
Blazer Dan G.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23996
Subject(s) - medicine , perioperative , confounding , proportional hazards model , radiation therapy , surgery , sarcoma , retrospective cohort study , soft tissue sarcoma , survival analysis , primary tumor , oncology , cancer , soft tissue , pathology , metastasis
Background Radiation therapy (RT) is increasingly utilized in conjunction with surgery for the treatment of retroperitoneal soft tissue sarcomas (RPS). Despite multiple theoretical advantages of RT, its role in the surgical management of this disease remains ill defined. Methods Patients undergoing surgery for RPS from 1990 to 2011 were identified. Patients were classified as having primary or recurrent disease, and then further stratified by the use of perioperative RT. Primary outcomes, including overall survival (OS) and recurrence‐free survival (RFS), were estimated using the Kaplan‐Meier method with comparisons based on the log rank test. Cox‐proportional hazards modeling was used to estimate the independent effect of RT on survival. Results Ninety‐four patients met final inclusion criteria. After adjusting for confounding variables, perioperative RT remained independently associated with a reduced risk of recurrence (HR 0.34, P < 0.01) and death (HR 0.30, P = 0.02). Conclusions In this retrospective series, perioperative RT is an independent predictor of improved OS and RFS. These results provide additional support for the use of RT in the multimodality treatment of retroperitoneal sarcoma. J. Surg. Oncol. 2015; 112:352–358 . © 2015 Wiley Periodicals, Inc.