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The prognostic significance and relationship with body composition of CCR7‐positive cells in colorectal cancer
Author(s) -
Malietzis George,
Lee Gui Han,
Bernardo David,
Blakemore Alexandra I. F.,
Knight Stella C.,
Moorghen Morgan,
AlHassi Hafid O.,
Jenkins John T.
Publication year - 2015
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.23959
Subject(s) - c c chemokine receptor type 7 , medicine , colorectal cancer , lymphovascular invasion , immunohistochemistry , tumor microenvironment , immune system , oncology , tissue microarray , biomarker , cancer , metastasis , chemokine , chemokine receptor , pathology , cancer research , receptor , immunology , biology , biochemistry
Background and Objectives The host local immune response (LIR) to cancer is a determinant of cancer outcome. Regulation of this local response is largely achieved through chemokine synthesis from the tumor microenvironment such as C‐Chemokine‐Receptor‐7 (CCR7). We examined the LIR measured as CCR7 expression, in colorectal cancers (CRC) and explored relationships with body composition (BC) and survival. Methods A study of paraffin‐embedded tissue specimens was carried out in 116 patients with non‐metastatic CRC. CCR7 expression was determined by immunohistochemistry. Analysis of computer tomography scans was used to calculate BC parameters. Survival analyses and multivariate regression models were used. Results High CCR7 + cell density within the tumor stroma and at the margin was significantly associated with increased age, the presence of lymphovascular invasion, higher tumor stage, lymph node metastasis, high Klintrup‐Makinen immune score, and myosteatosis. High CCR7 + cell density in the tumor margin was significantly associated with shorter disease‐free (DFS) and overall survival (OS) ( P < 0.001). This was also significantly associated with shorter survival in multivariate analysis (HR = 8.87; 95%CI [2.51–31.3]; P < 0.01 for OS and HR = 4.72; 95%CI (1.24–12.9); P = 0.02 for DFS). Conclusions Our results suggest that a specific immune microenvironment may be associated with altered host's BC and tumor behavior, and that CCR7 may serve as a novel prognostic biomarker. J. Surg. Oncol. 2015 111:86–92 . © 2015 Wiley Periodicals, Inc.